منابع مشابه
Genetic and electrophysiological studies of drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission
Cloning and characterization of the Drosophila syntaxin-1A gene, syx-1A, reveal that it is present in several tissues but is predominantly expressed in the nervous system, where it is localized to axons and synapses. We have generated an allelic series of loss-of-function mutations that result in embryonic lethality with associated morphological and secretory defects dependent on the severity o...
متن کاملTaurine and neurotransmission
Taurine is enriched in electrically excitable tissues such as brain, retina, heart and skeletal muscles. Since the 1960s it has been envisaged to act in the central nervous system as a neurotransmitter, neuromodulator, neuroprotector, membrane stabilizer, endogenous antiepileptic agent, cell volume regulator, and thought to maintain calcium homeostasis and membrane integrity [1]. Of the many pr...
متن کاملCatecholamine secretion in trout chromaffin cells experiencing nicotinic receptor desensitization is maintained by non-cholinergic neurotransmission.
The goal of the present study was to assess the catecholamine secretory capabilities of rainbow trout Oncorhynchus mykiss chromaffin cells experiencing desensitization of the nicotinic receptor. It was hypothesized that the potential to secrete catecholamines could be maintained under conditions of nicotinic receptor desensitization owing to activation of non-cholinergic release pathways. An in...
متن کاملDrosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission.
The sec6/8, or exocyst, complex is implicated in trafficking of secretory vesicles to fusion sites in the plasma membrane. Genetic analyses have been done primarily in yeast, where mutation of the eight protein subunits similarly disrupts polarized vesicle fusion. The goal of this study was to assay the sec6/8 complex in Drosophila, and specifically to test its widely hypothesized functions in ...
متن کاملAdrenergic Neurotransmission
This book is a record of papers and discussions first presented at the 33rd Ciba Foundation Study Group held in honor of Professor U. S. vonEuler. The participants assembled at this symposium are all experts in the field of adrenergic transmission, meeting to report on new and exciting developments in a field pioneered by vonEuler. The majority of papers describe to a large extent the research ...
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ژورنال
عنوان ژورنال: Nature
سال: 1993
ISSN: 0028-0836,1476-4687
DOI: 10.1038/364582a0